Home > Publications > List of Publications
List of Publications

The Autism Tissue Program (ATP) is proud to provide the following partial list of publications in peer reviewed scientific journals that were made possibleby the efforts of this program.  This list, and the success of this program, is resultant of the altruism of individuals and their families, in giving the Gift of Hope, and donating brain tissue to further our understanding of autism.  Without the partnership of these families with the ATP, this field of science and our understanding of autism would falter, and much of this research might never have occurred. 

Scientific articles

  1. S. Hossein Fatemi, Timothy D. Folsom, Teri J. Reutiman & Paul D. Thuras. 2009. Expression of GABAB Receptors Is Altered in Brains of Subjects with Autism.  Cerebellum 8:64–69.

  2. S. Hossein Fatemi, Teri J. Reutiman, Timothy D. Folsom and Paul D. Thuras. 2009. GABAA Receptor Downregulation in Brains of Subjects with Autism.  J Autism Dev Disord 39:223–230.

  3. Oblak A, Gibbs TT, Blatt GJ. 2009. Decreased GABAA receptors and benzodiazepine binding sites in the anterior cingulate cortex in autism.  Autism Res. 2009 Aug;2(4):205-19.

  4. Emily L. Williams, Manuel F. Casanova. Autism and dyslexia: a spectrum of cognitive styles as defined by minicolumnar morphometry. Med Hypotheses 2009; in press.

  5. Manuel F. Casanova, Ayman S. El-Baz, Jay Giedd, Judith M. Rumsey, Andrew E. Switala. Increased white matter gyral depth in dyslexia: implications for corticocortical connectivity. Journal of Autism and Developmental Disorders 2009; in press.

  6. Manuel F. Casanova, Ayman El-Baz, Eric Vanbogaert, Praveen Narahari, Andrew Switala. A topographic study of minicolumnar core width by lamina comparison between autistic subjects and controls: possible minicolumnar disruption due to an anatomical element in-common to multiple laminae. Brain Pathology 2009; in press.

  7. C Lintas, C, Sacco R, Garbett K, Mirnics K, Militerni R,Bravaccio C, Curatolo P, Manzi B, Schneider C, Melmed R, Elia M, Pascucci T, Puglisi-Allegra S, Reichelt K-L and AM Persico.  2009.  Involvement of the PRKCB1 gene in autistic disorder: significant genetic association and reduced neocortical gene expression. Molecular Psychiatry 14, 705–718

  8. Jerzy Wegiel1*, Thomas Wisniewski2, Abha Chauhan3, Ved Chauhan3, Izabela Kuchna1, Krzysztof Nowicki1, Humi Imaki1, Jarek Wegiel1, Shuang Yong Ma1, Teresa Wierzba Bobrowicz4, Ira Cohen5, Eric London5, W.Ted Brown6  2009.  Type, Topography And Sequelae Of Neuropathological Changes  Shaping Clinical Phenotype Of Autism   .    In: Autism: Oxidative Stress, Inflammation and Immune Abnormalities.   Editors: A. Chauhan, V. Chauhan, W. Ted Brown.  Publisher: Taylor & Francis/CRC, Boca Raton.

  9. Casanova MF, El-Baz A, Mott M, Mannheim G, Hassan H, Fahmi R, Giedd J, Rumsey JM, Switala AE, Farag A.  2009.  Reduced Gyral Window and Corpus Callosum Size in Autism: Possible Macroscopic Correlates of a Minicolumnopathy.  J Autism Dev Disord. Jan 16. [Epub ahead of print]

  10. Abuhatzira L, Shemer R, Razin A. MeCP2 involvement in the regulation of neuronal alpha-tubulin production.Hum Mol Genet. 2009 Apr 15;18(8):1415-23. Epub 2009 Jan 27.

  11. Yip, Jane, Soghomonian, Jean-Jacques and Gene J. Blatt.  2008. Increased GAD67 mRNA Expression in Cerebellar Interneurons in Autism: Implications for Purkinje Cell Dysfunction Journal of Neuroscience Research 86:525–530.

  12. Whitney,  Elizabeth R., Kemper, Thomas L., Bauman, Margaret L., Rosene, Douglas L. & Gene J. Blatt.  2008.  Cerebellar Purkinje Cells are Reduced in a Subpopulation of Autistic Brains: A Stereological Experiment Using Calbindin-D28k.  Cerebellum 7:406–416.

  13. Whitney,  Elizabeth R., Kemper, Thomas L., Rosene, Douglas L., Bauman, Margaret L. & Gene J. Blatt.  2008. Calbindin-D28k is a more reliable marker of human Purkinje cells than standard Nissl stains: A stereological experiment.  Journal of Neuroscience Methods 168:42–47.

  14. Palmieri L, Papaleo V, Porcelli V, Scarcia P, Gaita L, Sacco R, Hager J, Rousseau F, Curatolo P, Manzi B, Militerni R, Bravaccio C, Trillo S, Schneider C, Melmed R, Elia M, Lenti C, Saccani M, Pascucci T, Puglisi-Allegra S, Reichelt KL, Persico AM.  2008. Altered calcium homeostasis in autism-spectrum disorders: evidence from biochemical and genetic studies of the mitochondrial aspartate/glutamate carrier AGC1. Mol Psychiatry. Jul 8. [Epub ahead of print]

  15. ANP paper submission under revision– not for report yet… Alterations of von Economo neurons in the anterior cingulate cortex and frontoinsular cortex in schizophrenia and autism. Imke A.J. van Kooten1,2,3*, Devorah Segal4*, Bart P. F. Rutten1,2, Pawel Kreczmanski1,2, Herman van Engeland3, Harry W.M. Steinbusch1,2, Helmut Heinsen5, John M. Allman6, Christoph Schmitz1,2,7,*, and Patrick R. Hof4,

  16. Maussion G, Carayol j, Lepagnol-Bestel A-M, Tores F, Loe-Mie T, Milbreta U, Rousseau F, Fontaine K, Renaud J, Moalic J-M, Philippi A, Chedotal A, Gorwood P, Ramoz N, Hager j and Michel Simonneau.  2008. Convergent evidence identifying MAP/microtubule affinity regulating kinase 1 (MARK1) as a susceptibility gene for autism. Human Molecular Genetics 17:1-11 

  17. Kawther Abu-Elneel, Tsunglin Liu, Francesca S Gazzaniga, Yuhei Nishimura, Dennis P Wall, Daniel H Geschwind, Kaiqin Lao, Kenneth S Kosik. 2008.  Heterogeneous Dysregulation of microRNAs across the Autism Spectrum.  Neurogenetics 9:153-161. 

  18. Lepagnol-Bestel AM, Maussion G, Boda B, Cardona A, Iwayama Y, Delezoide AL, Moalic JM, Muller D, Dean B, Yoshikawa T, Gorwood P, Buxbaum JD, Ramoz N, Simonneau M.  2008. SLC25A12 expression is associated with neurite outgrowth and is upregulated in the prefrontal cortex of autistic subjects. Mol Psychiatry. 2008 Apr;13(4):385-97. Epub 2008 Jan 8.

  19. Van Kooten, IAJ,  Palmen, SJMC, von Cappeln, P; Steinbusch, HWM, Korr, H, Heinsen, H, Hof, PR, van Engeland, H & C Schmitz.  2008.  Neurons in the fusiform gyrus are fewer and smaller in autism.  Brain 131:987-999.

  20. Schmitz C &  Rezaie P. 2008. The neuropathology of autism: where do we stand? Neuropathol Appl Neurobiol. 34(1):4-11.

  21. Kulesza, RJ & K Mangunay. 2008. Morphological features of the medial superior olive in autism. Brain Res.  Brain Res. 2008 Jan 14; [Epub ahead of print]

  22. Evans, TA, Siedlak, SL, Lu, L, Fu, X, Wang, Z, McGinnis, WR, Fakhoury, E, Castellan, RJ, Hazen, SL, Walsh, WJ, Lewis, AT, Salomon, RG, Smith, MA, Perry G & X. Zhu  2008.  The Autistic Phenotype Exhibits a Remarkably Localized Modification of Brain Protein by Products of Free Radical-Induced Lipid Oxidation    American Journal of Biotechnology and Biochemistry 4 (2): 61-72.

  23. Sajdel-Sulkowska, EM, Lipinski, B, Windom, H, Audhya, T and W McGinnis.  2008.  Oxidative Stress in Autism: Elevated Cerebellar 3-nitrotyrosine Levels.  American Journal of Biochemisty and Biotechnology 4:73-84.

  24. López-Hurtado, Edith and Jorge J. Prieto. 2008. A Microscopic Study of Language-Related Cortex in Autism American Journal of Biochemisty and Biotechnology 4:130-145.

  25. Campbell, Daniel B.; D’Oronzio, Rosanna; Garbett, Krassi; Ebert, Philip J.; Mirnics, Karoly; Levitt, Pat and Antonio M. Persico.  2007. Disruption of Cerebral Cortex MET Signaling in Autism Spectrum Disorder.  Ann Neurol 62:243-250.

  26. Gregg JP, Lit L, Baron CA, Hertz-Picciotto I, Walker W, Davis RA, Croen LA, Ozonoff S, Hansen R, Pessah IN, Sharp FR. Gene expression changes in children with autism. Genomics. 2008 Jan;91(1):22-9. Epub 2007 Nov 14.

  27. Kennedy, DP, Semendeferi, K and E Courchesne. 2007.  No reduction of spindle neuron number in frontoinsular cortex in autism.  Brain and Cognition 64:124–129.

  28. El-Baz, A.,  Casanova, MF, Gimel’farb, G., Mott,M. and Andrew E. Switwala  2007. A new image analysis approach for automatic classification of autistic brains. IEEE 352-355.
     
  29. Fahmi, R.,  El-Baz, AS, El Munim, HE, Farag, AA and MF Casanova. 2007. Classification techniques for autistic vs. typically developing brain using MRI data.  IEEE 1348-1351.

  30. Pardo, CA and CG Eberhart. 2007.  The Neurobiology of Autism (Symposium: Neurobiology of Autism).  Brain Pathology, 17:434-447.

  31. London, E. 2007. The Role of the Neurobiologist in Redefining the Diagnosis of Autism. (Symposium: Neurobiology of Autism).  Brain Pathology, 17:408-411.

  32. Casanova, MF. 2007.  The Neurobiology of Autism (Symposium: Neurobiology of Autism).  Brain Pathology. 17:422-33.

  33. Haroutunian, V and J Pickett.  2007.  Autism Brain Tissue Banking (Symposium: Neurobiology of Autism).  Brain Pathology, 17:412-421.

  34. Halladay, A, Demetrikopoulos, MK and J Pickett.  Autism Brain Tissue Research: Findings Presented at the 2006 IMFAR meeting.  Autism-Asperger’s Digest.  March-April 2007.

  35. Yip, J, Soghomonian, J-J & J. Blatt.  2007.  Decreased GAD67 mRNA levels in cerebellar Purkinje cells in autism: pathophysiology implications.  Acta Neuropathol.  Jan 18; [Epub ahead of print].

  36. Brimacombe M, Pickett J, Pickett R. 2007.  Autism Post-Mortem Neuroinformatic Resource: The Autism Tissue Program (ATP) Informatics Portal. J Autism Dev Disord Mar 37(3):574-9. 

  37. Eberhart, C, Copeland, J & T Abel.  2006.  Brief Report: S6 Ribosomal Protein Phosphorylation in Autistic Frontal Cortex and Cerebellum: a Tissue Array Analysis.  J Autism Dev Disord. 36:1131-1136.

  38. J. Hutsler, Tiffany Love, and Hong Zhang. 2006.  Histological and Magnetic Resonance Imaging Assessment of Cortical Layering and Thickness in Autism Spectrum Disorders.  Biological Psychiatry Mar 30; [Epub ahead of print]

  39. Nagarajan R, Hogart AR, Gwye Y, Martin MR & JM LaSalle.  2006.  Reduced MeCP2 Expression is Frequent in Autism Frontal Cortex and Correlates with Aberrant             MECP2 Promoter Methylation. Epigenetics 1:4, 172-182.

  40. Buxhoeveden, DB, Semendeferi, K, Buckwalter, J, Schenker, N, Switzer, R and E Courchesne.  2006.  Reduced minicolumns in the frontal cortex of patients with autism.  Neuropathology and Applied Neurobiology 32:1-9. 

  41. Eberhart CG, Copeland J, Abel TW.  2006. Brief Report: S6 Ribosomal Protein Phosphorylation in Autistic Frontal Cortex and Cerebellum: a Tissue Array Analysis.  J Autism Dev Disord. 2006 Jul 15; [Epub ahead of print]

  42. Casanova MF.  Neuropathological and genetic findings in autism: the significance of a putative minicolumnopathy. Neuroscientist. 2006 Oct;12(5):435-41.

  43. Casanova MF, van Kooten IA, Switala AE, van Engeland H, Heinsen H, Steinbusch HW, Hof PR, Trippe J, Stone J, Schmitz C.  2006.  Minicolumnar abnormalities in autism. Acta Neuropathol (Berl). Sep;112(3):287-303. Epub Jul 4.

  44. CM Schumann and DG Amaral. 2006. Stereological analysis of amygdala neuron number in autism J. Neuroscience 26: 7674-7679.

  45. Pickett et.al.  2006.  1998-2002 update on causes of death in autism [letter].  Journal of Autism and Developmental Disorders. [E-publication ahead of print]

  46. Akbarian S, Huang HS.  2006.  Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders.  Brain Res Brain Res Rev 2006 Jun 5;[epub ahead of print].

  47. Martchek M, Thevarkunnel S, Bauman M, Blatt G, Kemper T. (2006) Lack of evidence of neuropathology in the locus coeruleus in autism. Acta Neuropathol (Berl). 111:497-9.

  48. Pardo, CA, Vargas, DL & AW Zimmerman. 2005.  Immunity, neuroglia and neuroinflammation in autism.  International Review of Psychiatry, December 2005; 17(6): 485–495. 

  49. Pickett, J. & E. London. 2005.  The Neuropathology of Autism: A Review.  Journal of Neuropathology and Experimental Neurology.  64(11):1-11. 

  50. Blatt, G.J. (2005) GABAergic cerebellar system in autism: A neuropathological and developmental perspective.  Int. Rev. Neurobiol. 71:167-178.

  51. Schumann CM and Amaral DG. Stereological estimation of the number of neurons in the human amygdaloid complex. J Comp Neurol. 2005 Oct 31;491(4):320-9.

  52. Ray MA, Graham AJ, Lee M, Perry RH, Court JA, Perry EK. 2005. Neuronal nicotinic acetylcholine receptor subunits in autism: an immunohistochemical investigation in the thalamus. Neurobiol Dis. Aug;19(3):366-77.

  53. Redcay E & Courchesne E.  When is the brain enlarged in autism? A meta-analysis of all brain size Reports. Biol Psychiatry. 2005 Jul 1;58(1):1-9.

  54. Frenzel, C.  Tantalizing Clues; Hope for the Future through the Autism Tissue Program. 2005.  Autism Spectrum Quarterly, Winter 2005.

  55. Samaco RC, Hogart A, Lasalle JM.  2005.  Epigenetic overlap in autism-spectrum neurodevelopmental disorders: MECP2 deficiency causes reduced expression of UBE3A and GABRB3. Hum Mol Genet. Feb 15;14(4):483-92. Epub 2004 Dec 22.

  56. Samaco RC, Nagarajan RP, Braunschweig D, LaSalle JM. (2004) Multiple pathways regulate MeCP2 expression in normal brain development and exhibit defects in autism-spectrum disorders. Hum Mol Genet. 2004 Mar 15;13(6):629-39.

  57. Courchesne E. 2004. Brain Development in autism: early overgrowth followed by premature arrest of growth.  Ment Retard Dev Disabil Res Rev.10(2):106-11.

  58. Lee DA, Lopez-Alberola R, Bhattacharjee M.  Childhood autism: a circuit syndrome? Neurologist. 2003 Mar;9(2):99-109.

  59. Casanova MF, Buxhoeveden D, Gomez J. 2003 Disruption in the inhibitory architecture of the cell minicolumn: implications for autism. Neuroscientist Dec;9(6):496-507

  60. Frenzel, Connie. An update on autism brain tissue research; a summary of the 2002 IMFAR research findings.  Autism-Asperger’s Digest  Nov-Dec 2003.

  61. Jiang, Y-H., Sahoo, T., Michaelis, R.C.,  Bercovich, D., Bressler, J., Kashork, C.D.,  Liu, Q., Shaffer, L.G., Schroer,R.J.,  Stockton, D.W., Spielman, R.S., Stevenson, R.E. &  Beaudet; A.L.  2004.  A mixed epigenetic/genetic model for oligogenic inheritance of autism with a limited role for UBE3A.  Am J Med Genet A. Nov 15;131(1):1-10.

  62. Junaid, M.A., Kowal, D., Barua, M., Pullarkat, P.S., Skower-Brooks, S., and Pullarkat, R.K.(2004) Proteomic studies identified a single nucleotide polymorphism in glyoxalase I as autism susceptibility factor. Am J Med Genet 2004 Sep 22;[epub ahead of print].

  63. Martin-Ruiz CM, Lee M, Perry RH, Baumann M, Court JA, Perry EK. 2004. Molecular analysis of nicotinic receptor expression in autism.  Brain Res Mol Brain Res.  Apr 7;123(1-2):81-90.

  64. Palmen SJ, van Engeland H, Hof PR, Schmitz C. 2004.  Neuropathological findings in autism.  Brain. 2004 Dec;127(Pt 12):2572-83. Epub 2004 Aug 25.

  65. Pickett, J. (2003) Autism Tissue Program: The Gift of Hope.  Exceptional Parent Magazine. Vol. 33 (6): 106-109.

  66. Vargas D.L., Nascimbene, C. Krishnan, C. Zimmerman, A.W. and Pardo, C.A.  2005.  Increased neuroglial activation and neuroinflammation in the brain of patients with autism.  Annals of Neurology 57(1):67-81.

  67. Mukaetova-Ladinska EB, Arnold H, Jaros E, Perry R, Perry E. 2004. Depletion of MAP2 expression and laminar cytoarchitectonic changes in dorsolateral prefrontal cortex in adult autistic individuals. Neuropathol Appl Neurobiol. 2004 Dec;30(6):615-23.

  68. Perry EK, Lee ML, Martin-Ruiz CM, Court JA, Volsen SG, Merrit J, Folly E, Iversen PE, Bauman ML, Perry RH, Wenk GL. 2001. Cholinergic activity in autism: abnormalities in the cerebral cortex and basal forebrain. Am J Psychiatry. 2001 Jul;158(7):1058-66.

  69. Fatemi SH, Stary JM, Halt AR, Realmuto GR.  2001. Dysregulation of Reelin and Bcl-2 proteins in autistic cerebellum.  J Autism Dev Disord. 2001 Dec;31(6):529-35.

  70. Gene J. Blatt, G.J., Fitzgerald, C.M., Guptill, J.T., Booker, A.B., Kemper, T.L. & Bauman, M.L. (2001).  Density and distribution of hippocampal neurotransmitter receptors in autism: An autoradiographic study.  Journal of Autism and Developmental Disorders 31: 537-544.  
     
  71. Junaid, M.A. & Pullarkat, R. K. (2001). Proteomic approach for the elucidation of biological defects in autism.  Journal of Autism and Developmental Disorders 31: 557-560. 

  72. Hemby, S.E., Sanchez, M.M. & Winslow, J.T.  (2001). Functional Genomics Approaches to A Primate Model of Autistic Symptomology. Journal of Autism and Developmental Disorders 31: 551-556.

  73. Purcell, A.K., Jeon, O. & Pevsner, J. (2001). The Abnormal Regulation of Gene Expression in Autistic Brain. Journal of Autism and Developmental Disorders. 31: 545-550.
     
  74. Amy E. Purcell, Mary Margaret Rocco, Jennifer A. Lenhart, Karim Hyder, Andrew W.  Zimmerman, and Jonathan Pevsner. 2001.  Assessment of neural cell adhesion molecule  (NCAM) in autistic serum and postmortem brain. Journal qf Autism and Developmental Disorder 31, 2:183-194, 2001.

  75. Schumann, C.M., Buonocore, M.H. & Amaral, D.G. (2001).  MRI of the Post-Mortem Autistic Brain  Journal of Autism and Developmental Disorders 31: 561-569.
          
  76. Shavelle, R., Strauss, R. and Pickett, J.  (2001). Causes of Death in Autism.  Journal of Autism and Developmental Disorders 31: 569-576.  

  77. Shavelle, R.M., Strauss, D.J. & Pickett, J.A. (2001). Listing of causes of death of persons with autism in California 1983-1987.  Website:  http://www.LifeExpectancy.com/autism.html.

  78. Pickett, J. (2001) Current Investigations in Autism Brain Tissue Research.  Journal of Autism and Developmental Disorders 31: 521-527